The HIV Correlation - LIFE OR METH

46% of MSM meth users
face GREATER RISK of HIV
infection, says recent US
study that establishes an
independent, CAUSATIVE
link. Poppers also a factor.

46% of men who have sex with men (MSM) who use crystal face greater risk of HIV infection, says a new US study that establishes an independent, causative link between the two.

The study confirms that, when combined with other risk factors like unprotected receptive anal intercourse with multiple partners, meth increases the chances of seroconversion substantially, and also reports a threefold increase in the risk of acquiring HIV among those with a history of meth and popper use compared to those not using either drug. The analysis, reported by researchers associated with the Multicenter AIDS Cohort Study (MACS), will be published in a forthcoming issue of the authoratitive Journal of Acquired Immune Deficiency Syndromes.

Previous behavioral studies into the link between meth use and HIV infection have served to demonstrate that MSM meth users are more likely to engage in high-risk sexual practices, putting them at an increased risk for HIV and other sexually transmitted infections. While such studies have shown that a correlation between meth use and HIV infection among MSM existed, they did not support the hypothesis of causation between the two, which the MACS does.

"The strength of the MACS," according to David Ostrow, MD, PhD, of the Chicago MACS Centre and a member of the research team, "is that it is a relatively stable population of gay and bisexual men that has been followed prospectively since 1984, at the very beginning of the scientific study of the natural history of AIDS, with additional men recruited in 1987 to 1988 and 2000 to 2001. Given the semi-annual visits at which both behavioral and medical, as well as HIV testing and assessment is performed, we can look at causal relationships between sexual or drug behaviors and seroconversion, even though the exact nature of that causality is not necessarily elucidated in the study."

Of the 6973 negative and positive MSM recruited into the MACS study, between 23 and 28% seroconverted at some point, while a similar number remained negative. 4,003 MSM who were HIV- upon entering the study were included in the meth analysis. Those who seroconverted were similar to those who remained negative in terms of age, race/ethnicity and educational levels but were more likely to have used meth, poppers, cocaine or ecstasy during participation, and 94% reported having unprotected receptive anal sex on at least one occasion.

In light of the new findings, Dr. Ostrow advocates moving beyond criticism of studies that don't fully elucidate the causal relationship between meth use and HIV risk, particularly by numeorus Western HIV/gay men's sexual health organisations who have waited years for such proof to emerge, and who have used the lack of conclusive data to avoid taking effective action against meth.

"It is dangerous to rely on the lack of a 'smoking gun' in terms of the exact mechanism to deny the need to recognise and change one's behavior to avoid HIV infection or transmission," Dr. Ostrow said. "This is analogous to the public outcry when I and others suggested in 1982 that gay men refrain from unprotected anal intercourse until we knew what was causing AIDS, as we definitely knew that unprotected anal sex was the leading route of infection or exposure to whatever the causal factor would turn out to be." [See AID$ INC. UNCOVERED]

"In a study of HIV+ individuals being treated with highly active antiretroviral therapy (HAART), current meth users had higher plasma viral loads than those who were not currently using meth, suggesting that HIV+ meth users on HAART therapy may be at greater risk of developing AIDS."

~NIDA

Researchers at the University of Buffalo have found that methamphetamine promotes the spread of HIV-1 in users infected with the virus due to physiological changes that favour transmission. Ingestion of meth increases production of a "docking" protein that enables the spread of the HIV-1 virus said Madhavan P. N. Nair, a professor of medicine and a specialist in immunology in the University's School of Medicine and Biomedical Sciences, and lead author of the study. "This finding shows that using meth is doubly dangerous," he said. "Meth reduces inhibitions thus increasing the likelihood of risky sexual behavior and the potential to introduce the virus into the body, and at the same time allows more virus to get into the cell."

It is now being debated whether meth's ravaging effect on the immune system actually replicates many of the symptoms associated with full-blown AIDS regardless of whether HIV - or rather the antibodies that suggest infection - is present, in much the way that AZT is increasingly suspected of inducing and accelerating full-

blown AIDS symptoms and premature death in patients due to its high toxicity. Some MSM believed to be immune to contracting HIV, perhaps due to a rare protective protein in their blood, have developed full-

blown AIDS only since becoming addicted to crystal.

MSM who used meth in the last year were found to be five times more likely to seroconvert than MSM who did not use, according to preliminary data collected by the Los Angeles Gay & Lesbian

Centre from 6,360 men it tested in 2006 for HIV and other STIs.

The centre also found that 25% of all MSM reported using meth at least once during the period, compared with 18% of the 5,300 MSM it tested in 2005, with 43% of those newly-infected with HIV reporting some meth use. "There's no doubt in the minds of most experts that meth contributes not only to the transmission of HIV but other STIs," said Jonathan Fielding, director of the Los Angeles County Department of Public Health. The findings have once again prompted a news conference to increase public awareness about meth use along with a forum in West Hollywood to discuss expanded treatment options.

Meanwhile, the LA County Department of Public Health has reported that around 10% of all MSM reported using crystal within a six-month period - a frequency about 20 times greater than in the general population. Meth has become the number one drug used by individuals seeking treatment in LA county-funded programs, with abuse rising across all demographic groups between 2001 and 2005. The county has funded three new HIV/meth-prevention programs addressing the disease and drug use aimed specifically at MSM.

"At least 25% of occasional meth users are HIV+. This number rises to 40% in chronic users. At outpatient treatment centres 60% of clients are HIV+, while 90% of inpatient programs' patients are HIV+. In fact, meth users are more likely than heroin users to be HIV+."

~ Dan Bowers [HIV Plus ]

Because meth stimulates the central nervous system and focuses the user's mind on the present moment, all fears anchored in the past and future - including those based around HIV and AIDS - evaporate along with his inhibitions, and his deluded feeling of invincibility induced by the sensory high can easily tempt and persuade him to overlook his responsibility to protect both himself and his partner.

Paradoxically, meth is used by some MSM specifically to disassociate from the fear attached to sex in the post-AIDS era. Combination therapies, protease inhibitors and other drugs in development are often cited as justification for unprotected sex, although there remains no cure or vaccine for AIDS, which continues to be a chronic and deadly disease. A 2005 survey in Los Angeles found that 7% of HIV- men took an AIDS medication before engaging in risky behavior believing that they would be protected against HIV.

"People have safe sex fatigue; they are fed up of having to be afraid of HIV. In these circumstances, crystal is the perfect Petri dish for transmission."

~ Peter Staley [Founder of AIDS Meds ]

The results of a study by San Francisco's University of California reveal conclusively that meth use by HIV+ people:

• Quadruples the risk of unprotected insertive sex with an HIV- person or a person of unknown status;

• Increases the risk of transmitting drug-resistant strains of HIV;

• Raises the risk of having unsafe sex with a partner of unknown status if used with Viagra.

The union of crystal and Viagra - and, to an extent, recreational drugs like GHB - has boosted the HIV transmission rate across the States in recent years, and a similar pattern is emerging in other countries where meth is gaining a foothold in urban gay communities. A 2005 London study found that a fifth of all HIV+ men in the city had used meth in the previous 12 months - twice the number of HIV- men - increasing to over 30% for those with multiple partners.

HIV+ men are increasingly self-medicating with crystal meth in order to:

• Erase chronic fatigue syndrome;

• Alleviate the often unpleasant physical and psychological symptoms arising from the endless cocktail of often highly toxic drugs they are prescribed;

• Quell feelings of hopelessness and despair, "survivor guilt" and the spectre of death, especially among those living in AIDS-ravaged ghettoes ;

• Temper negative self-perceptions and social rejection associated with being positive.

Together with the rediscovered appetite for sex that crystal triggers, HIV+ users argue that the crash is a price worth paying, even though it is by far the worst drug possible for those with HIV because it:

• Accelerates HIV replication five to 15 times faster than the replication of HIV not exposed to meth - thereby triggering the onset of full-blown AIDS - due to the erosion of the immune system caused by missed meals, vitamin depletion, weight loss and disrupted sleep patterns;

• Ravages and depletes T-cell counts at an alarming rate by impairing the function of cytotoxic lymphocytes, which are critical for the immune system's first response to HIV, meaning that the user will need to go on medications sooner than he otherwise would have done (a HIV+ New Yorker is reported to have lost 250 T-cells over one weekend binge);

• Boosts viral loads and susceptibility to illnesses because the mind-impaired abuser frequently forgets to take his time sensitive dosages of HIV medication;

• Heightens the body's susceptibility to other strains of HIV (superinfection) and STDs;

• In hibits the effectiveness of HIV medications and increases drug-resistance (26% of meth users in a US study group were resistant to at least one drug, and regular users were 2.3 times more likely to have drug-resistant HIV than non-users and 3.9 times more likely to have resistance to efavirenz and/or nevirapine).

• Floods the brain when used with protease inhibitors because it shares the same liver processing pathway, increasing the likelihood of addiction and brain damage (Amprenavir alone boosts the amount of meth in the bloodstream two-to-threefold, putting the user at risk of overdosing);

• Exacerbates dopamine depletion (HIV+ infection alone destroys 12-20% of dopamine-associated brain cells), inducing an accelerated form of dementia (basal ganglia dysfunction) and Parkinson's-like movement disorders and loss of verbal skills (concurrent meth abuse and HIV infection appears to result in far greater impairment than each condition alone);

• Damages the lining of the blood vessels in the brain allowing more HIV-infected cells to reach there, which can lead to HIV encephalitis (brain inflammation);

• Is a long-acting, indirect sympathomimetic and far more immuno-suppressive than HIV, leaving someone immuno-suppressed for days on end regardless of whether they are positive or negative;

• Increases the risk of rhabdomyolysis - a potentially fatal disease that destroys skeletal muscle - if the user needs to take a statin to lower cholesterol levels.

The Centres for Disease Control and Prevention estimates the US HIV infection rate among MSM has risen 14% since 1999 - the biggest increase since the epidemic began over 25 years ago.

It recorded an 8% increase in HIV diagnoses among MSM between 2003 and 2004 alone after several years of relatively stable data. "We don't yet have all of the answers regarding the factors driving these trends," Ronald Valdiserri, acting director of the CDC's National Center for HIV, STD and Tuberculosis Prevention, said at the time.

"All our current research says that the vast majority of gay men are not using a condom every time they have sex."

~ Michael Shernoff [HIV+ gay psychotherapist]

HIV+ men who engage in unprotected sex with each other (serosorting ) are at risk of catching or transmitting more virulent and drug-resistant mutant strains of the virus. Re-infection (superinfection) can destroy the immune control built up fighting the original strain, jeopardising the progress of AIDS vaccines already in development. Some highly sexually active men who were assumed to be immune to catching HIV have seroconverted since succumbing to crystal, which is shown in tests to destroy the rare protective protein in their cellular make-up.